Publications: Peer-reviewed journal articles (by staff)

Hantupeptin A, a cytotoxic cyclic depsipeptide from a Singapore collection of Lyngbya majuscula

  • Tripathi A,
  • Puddick J,
  • Prinsep MR, Lee PPF,
  • and Tan LT
18 December, 2008
CITATION

Tripathi A, Puddick J, Prinsep MR, Lee PPF, Tan LT 2008 Hantupeptin A, a cytotoxic cyclic depsipeptide from a Singapore collection of Lyngbya majuscula. Journal of Natural Products, 72: 29-32.

DOI link here

ABSTRACT

Chemical investigation of the marine cyanobacterium Lyngbya majuscula from Pulau Hantu Besar, Singapore, has led to the isolation of a cyclodepsipeptide, hantupeptin A (1). The planar structure of 1 was assigned on the basis of extensive 1D and 2D NMR spectroscopic experiments. The absolute configuration of the amino and hydroxyl acid residues in the molecule was determined by application of the advanced Marfey method, chiral HPLC analysis, and Mosher’s method. Hantupeptin A showed cytotoxicity to MOLT-4 leukemia cells and MCF-7 breast cancer cells with IC50 values of 32 and 4.0 µM, respectively.